The E3 Ubiquitin Ligase SMAD Ubiquitination Regulatory Factor 2 Negatively Regulates Krüppel-like Factor 5 Protein
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چکیده
منابع مشابه
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CCAAT/Enhancer Binding Protein Alpha (C/EBPα) is a key transcription factor involved in the adipocyte differentiation. Here for the first time we demonstrate that E6AP, an E3 ubiquitin ligase inhibits adipocyte differentiation in 3T3-L1 cells as revealed by reduced lipid staining with oil red. Knock down of E6AP in mouse 3T3L1 preadipocytes is sufficient to convert them to adipocytes independen...
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متن کاملکاهش بیان ژن Smurf2 Smad ubiquitin regulatory factor 2)) در بیماران مبتلا به RRMS و همراهی با افزایش میزان ناتوانی
چکیده زمینه و هدف: بیماری مالتیپل اسکلروزیس(MS)، یک بیماری التهابی مزمن در دستگاه عصبی مرکزی میباشد، که با تخریب غلاف میلین سلولهای عصبی همراه است. یکی از مهمترین سیتوکینهایی که در استعداد و یا تعدیل بیماری MS نقش دارد، فاکتور تغییر دهندهی رشد بتا(TGF-B) میباشد. ژن smurf2 نقش مهمی‌در تعیین صلاحیت سلول در پاسخ به مسیر سیگنالینگ TGF-β دارد. بنابراین هدف از مطالعه حاضر مشخص شدن نقش ژن smurf2...
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Loss-of-function mutations in the Arabidopsis thaliana ENHANCED DISEASE RESISTANCE1 (EDR1) gene confer enhanced programmed cell death under a variety of abiotic and biotic stress conditions. All edr1 mutant phenotypes can be suppressed by missense mutations in the KEEP ON GOING gene, which encodes a trans-Golgi network/early endosome (TGN/EE)-localized E3 ubiquitin ligase. Here, we report that ...
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Loss-of-function mutations in the Arabidopsis thaliana ENHANCED DISEASE RESISTANCE1 (EDR1) gene confer enhanced programmed cell death under a variety of abiotic and biotic stress conditions. All edr1 mutant phenotypes can be suppressed by missense mutations in the KEEP ON GOING gene, which encodes a trans-Golgi network/early endosome (TGN/EE)localized E3 ubiquitin ligase. Here, we report that E...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2011
ISSN: 0021-9258
DOI: 10.1074/jbc.m111.258707